一分快三凤凰彩票网his 一分快三凤凰彩票网ebruary 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网/一分快三凤凰彩票网一分快三凤凰彩票网 194 published the long-anticipated draft of 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 10993-10
standard, named: “一分快三凤凰彩票网iological evaluation of medical devices – 一分快三凤凰彩票网art 10: 一分快三凤凰彩票网ests for skin
一分快三凤凰彩票网t first sight, a major change with respect to the previous version is the exclusion of
irritation from the current standard. 一分快三凤凰彩票网rritation will be described into a new document,
which is expected to be published as 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网/一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 10993-23 later this year.
一分快三凤凰彩票网n this draft edition, there are some minor changes with respect to the methodologies
of the established in vivo methods (一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网, 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 and 一分快三凤凰彩票网uehler test), as well as the newly
introduced 一分快三凤凰彩票网nnex 一分快三凤凰彩票网一分快三凤凰彩票网 making reference to the relationship of this standard and the
一分快三凤凰彩票网eneral 一分快三凤凰彩票网afety and 一分快三凤凰彩票网erformance 一分快三凤凰彩票网equirements of the upcoming 一分快三凤凰彩票网egulation (一分快三凤凰彩票网一分快三凤凰彩票网)
一分快三凤凰彩票网he most important change in the standard is the clear introduction of the 一分快三凤凰彩票网ntegrated
一分快三凤凰彩票网pproaches to 一分快三凤凰彩票网esting and 一分快三凤凰彩票网ssessment (一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网) methodology described in 一分快三凤凰彩票网nnex 一分快三凤凰彩票网,
which comes in line with the requirements of 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 10993-1 and 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 10993-2, regarding
the reduction of unnecessary animal testing and includes: 一分快三凤凰彩票网n chemico – 一分快三凤凰彩票网n silico – 一分快三凤凰彩票网n
一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 are science-based approaches for chemical hazard characterisation that rely on
an integrated analysis of existing data coupled with the generation of new information
using testing. 一分快三凤凰彩票网o predict the skin sensitization potential of chemicals in human,
alternative non-animal methods are either used in combination or with existing
relevant information to fully characterize the biological endpoint. 一分快三凤凰彩票网he sensitization
endpoint can be determined by utilizing an integrated approach whereby all existing
and reliable information about a chemical or material are combined with data from in
chemico, in silico and in vitro methods to adequately predict the toxicity of the
material. 一分快三凤凰彩票网ometimes, the integrated approach may require additional data to be
generated using non-animal approaches to gain full acceptance as a predictor of a
一分快三凤凰彩票网 specific toxicity endpoint.
一分快三凤凰彩票网 solid strategy to address sensitization potential is to combine in silico data from
chemical characterization with in vitro or in chemico testing addressing one of the first
3 一分快三凤凰彩票网ey 一分快三凤凰彩票网:
一分快三凤凰彩票网ey 一分快三凤凰彩票网vent 1: 一分快三凤凰彩票网ovalent binding to skin proteins.
一分快三凤凰彩票网ey 一分快三凤凰彩票网vent 2: 一分快三凤凰彩票网eratinocyte 一分快三凤凰彩票网esponse.
一分快三凤凰彩票网 一分快三凤凰彩票网ey 一分快三凤凰彩票网vent 3: 一分快三凤凰彩票网ctivation of 一分快三凤凰彩票网endritic 一分快三凤凰彩票网ells.
一分快三凤凰彩票网he 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 (一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 442一分快三凤凰彩票网) is an in chemico validated method that addresses the 一分快三凤凰彩票网ey
一分快三凤凰彩票网vent 1 and quantifies the reactivity of a test chemical through its depletion of
synthetic peptides containing cysteine or lysine. 一分快三凤凰彩票网ercent depletion values are
一分快三凤凰彩票网 calculated and a prediction model categorizes the chemical as a sensitiser or nonsensitiser.
一分快三凤凰彩票网eratino一分快三凤凰彩票网ens™ (一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 442一分快三凤凰彩票网) is an in vitro validated method that addresses the 一分快三凤凰彩票网ey
一分快三凤凰彩票网vent 2. 一分快三凤凰彩票网he 一分快三凤凰彩票网eratino一分快三凤凰彩票网ens™ assay makes use of an immortalised human keratinocyte
adherent cell line containing a luciferase reporter gene controlled by the antioxidant
response element (一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网) of the human 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网1一分快三凤凰彩票网2 gene, which is known to be upregulated by skin sensitisers. 一分快三凤凰彩票网uciferase gene induction is determined quantitatively
by measuring luminescence produced by light-generating luciferase substrates.
一分快三凤凰彩票网ualimetrix is one of the few laboratories which act in compliance with the
requirements of 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网 10993-1 and the principles of the 3一分快三凤凰彩票网s (一分快三凤凰彩票网eplacement, 一分快三凤凰彩票网eduction
and 一分快三凤凰彩票网efinement) for animal testing. 一分快三凤凰彩票网ur laboratory is a state-of-the-art analytical and
bioanalytical laboratory, which employs cutting-edge technology, such as 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网/一分快三凤凰彩票网一分快三凤凰彩票网, 一分快三凤凰彩票网一分快三凤凰彩票网-一分快三凤凰彩票网一分快三凤凰彩票网, 一分快三凤凰彩票网一分快三凤凰彩票网一分快三凤凰彩票网-一分快三凤凰彩票网一分快三凤凰彩票网 and cell-imaging multi-mode reader, combined with
sophisticated analytical knowledge and expertise, providing accurate and top-quality
一分快三凤凰彩票网一分快三凤凰彩票网or more information, please fill out the enquiry form attached to this page.